Doxorubicin p53 activation synthesis - 3-Dependent Activation of a Molecular Beacon in
Cisplatin also inhibited the synthesis of HIF-1α protein for which p53 was dispensable. Although doxorubicin inhibited hypoxic activation of HIF-1,
21 transcriptional activation is mediated by p53 in response to DNA damage . Cells change their transcriptional profile as they respond to cellular stress.
Doxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes? p53 via ERK2 activation in doxorubicin
The p53 system is highly stress sensitive and integrates diverse intracellular signals in a complex and poorly defined manner. We report on the high dependence of stress-induced p53 activation on mitochondrial activity.
The hnRNPC interaction destabilizes p53 and prevents its activation. Doxorubicin we treated control and hnRNPC‐knockdown cells with the protein synthesis
he Major Side-effect of Doxorubicin for P53 activation in response to doxorubicin- facilitate replication and DNA synthesis, B) doxorubicin forms a complex